2-氨基-2-脱氧糖的C-糖苷。β-C-糖苷和1,1-二取代变体。

C-Glycosides of 2-amino-2-deoxy sugars. beta-C-Glycosides and 1,1-disubstituted variants.

作者信息

Liu Yan, Gallagher Timothy

机构信息

School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.

出版信息

Org Lett. 2004 Jul 8;6(14):2445-8. doi: 10.1021/ol0491540.

DOI:10.1021/ol0491540

PMID:15228300

Abstract

[reaction: see text] C(1)-Substituted anomeric selenides, derived from azidoselenation of C(1)-methylated glycals, provide access to anomeric radical reactivity that has been used to generate beta-C-glycosides and 1,1-disubstituted C-glycosides based on galacto, gluco, and manno variants of N-acetyl-2-amino sugars.

摘要

[反应：见正文] 由C(1)-甲基化糖烯的叠氮硒化反应得到的C(1)-取代异头硒化物，可实现异头自由基反应活性，该活性已被用于基于N-乙酰-2-氨基糖的半乳糖、葡萄糖和甘露糖变体生成β-C-糖苷和1,1-二取代C-糖苷。