Mookhoek Evert J, Loonen Anton J M
Deltabouman Psychiatric Teaching Hospital, PO Box 800, 3170 DZ Poortugaal, The Netherlands.
Pharm World Sci. 2004 Jun;26(3):180-2. doi: 10.1023/b:phar.0000026808.97403.05.
To study the effect of the replacement of omeprazole by pantoprazole on clozapine metabolism in 13 psychiatric patients, who used both clozapine and omeprazole.
Retrospective study of the medical files.
In comparison to smokers, a significant rise of the serum clozapine levels was observed in all non-smoking patients, whilst the daily dose of clozapine remained unchanged. This effect was probably caused by the discontinuation of enzyme induction of the cytochrome P450 enzyme 1A2 by omeprazole in non-smokers, whereas CYP1A2 remained induced in patients who smoked.
Omeprazole only influenced clozapine metabolism in non-smokers. In none of the patients an adjustment of the clozapine dose was required.
研究在13名同时使用氯氮平和奥美拉唑的精神科患者中，用泮托拉唑替代奥美拉唑对氯氮平代谢的影响。
对病历进行回顾性研究。
与吸烟者相比，所有非吸烟患者的血清氯氮平水平显著升高，而氯氮平的日剂量保持不变。这种效应可能是由于奥美拉唑在非吸烟者中停止了细胞色素P450酶1A2的酶诱导作用，而在吸烟患者中CYP1A2仍被诱导。
奥美拉唑仅影响非吸烟者的氯氮平代谢。所有患者均无需调整氯氮平剂量。
