Kowalski ester homologation. application to the synthesis of beta-amino esters.
作者信息
Gray Diane, Concellón Carmen, Gallagher Timothy
机构信息
School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
出版信息
J Org Chem. 2004 Jul 9;69(14):4849-51. doi: 10.1021/jo049562h.
PMID:15230615
Abstract
The Kowalski ester homologation protocol has been applied to a representative range of alpha-amino esters to provide beta-amino esters with excellent levels of enantio- and diastereocontrol. A key feature of this chemistry is the nature of the N-protecting group that is employed.
摘要
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