对人类皮层进行电刺激可抑制快速皮层活动和癫痫棘波。
Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes.
作者信息
Kinoshita Masako, Ikeda Akio, Matsumoto Riki, Begum Tahamina, Usui Keiko, Yamamoto Junichi, Matsuhashi Masao, Takayama Motohiro, Mikuni Nobuhiro, Takahashi Jun, Miyamoto Susumu, Shibasaki Hiroshi
机构信息
Departments of Neurology, Graduate School of Medicine, Kyoto Universtiy, Kyoto, Japan.
出版信息
Epilepsia. 2004 Jul;45(7):787-91. doi: 10.1111/j.0013-9580.2004.60203.x.
PURPOSE
To investigate underlying mechanisms and adequate parameters for electric cortical stimulation to inhibit epileptic focus in humans.
METHODS
A patient with intractable partial epilepsy had subdural electrodes implanted for preoperative evaluation. Cortical functional mapping was performed by using 50-Hz alternating square pulse of 0.3-ms duration, 1 to 7 mA, within 5 s. Spike frequency and electrocorticogram (ECoG) power spectra were compared before and after the stimulation when epileptic focus and distant area were stimulated. A similar comparison also was performed in low-frequency stimulation of 0.9 Hz applied for 15 min.
RESULTS
Interictal spikes were reduced after electric cortical stimulation of the epileptic area at a frequency of 50 Hz as well as 0.9 Hz, with concomitant decrease in the electrographic fast activities at 50-Hz stimulation.
CONCLUSIONS
These data suggest that electric cortical stimulation at both high and low frequency has a suppressive effect on epileptic activities in human cortex, possibly through distinct mechanisms.
目的
研究电刺激大脑皮层抑制人类癫痫病灶的潜在机制和合适参数。
方法
一名难治性部分性癫痫患者植入硬膜下电极进行术前评估。使用持续时间为0.3毫秒、频率为50赫兹的交变方波脉冲，电流强度为1至7毫安，在5秒内进行皮层功能映射。分别刺激癫痫病灶和远处区域，比较刺激前后的棘波频率和脑电图（ECoG）功率谱。对施加15分钟的0.9赫兹低频刺激也进行了类似比较。
结果
癫痫区域在50赫兹和0.9赫兹频率下进行电刺激后，发作间期棘波减少，同时50赫兹刺激时的脑电图快速活动也减少。
结论
这些数据表明，高频和低频电刺激大脑皮层对人类皮层癫痫活动均有抑制作用，可能通过不同机制实现。
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