Chrapko Wendy E, Jurasz Paul, Radomski Marek W, Lara Nathalie, Archer Stephen L, Le Mellédo Jean-Michel
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
Biol Psychiatry. 2004 Jul 15;56(2):129-34. doi: 10.1016/j.biopsych.2004.03.003.
Major depression (MD) has been associated with increased cardiovascular mortality in patients with coronary heart disease (CHD) and has been described as an independent risk factor for the development of CHD in healthy subjects; however, the mechanism of the association between MD and CHD remains to be determined. Nitric oxide (NO) plays a major role in cardiovascular regulation, and decreased NO production has been associated with several cardiovascular risk factors. We hypothesized that in patients with MD, NO production by both platelets and the endothelium would be reduced when compared with healthy control subjects (HCs).
Blood samples were obtained from 15 subjects with MD and 16 HCs with no known history of cardiovascular illness. Plasma NO metabolite (NOx) levels were analyzed by chemiluminescence. Platelet endothelial NO synthase (eNOS) activity was examined through the conversion of l-[(14)C]arginine to l-[(14)C]citrulline.
The levels of both plasma NOx and platelet eNOS activity were significantly lower in subjects with MD compared with HCs.
These data suggest that decreased NO production by the vascular wall and platelets might contribute to the increased CHD risk observed in patients with MD.
重度抑郁症（MD）与冠心病（CHD）患者心血管死亡率增加相关，且在健康受试者中被描述为冠心病发生的独立危险因素；然而，MD与CHD之间关联的机制仍有待确定。一氧化氮（NO）在心血管调节中起主要作用，NO生成减少与多种心血管危险因素相关。我们假设，与健康对照受试者（HCs）相比，MD患者血小板和内皮细胞的NO生成均会减少。
从15例MD患者和16例无心血管疾病病史的HCs中采集血样。通过化学发光分析血浆NO代谢产物（NOx）水平。通过将l-[(14)C]精氨酸转化为l-[(14)C]瓜氨酸来检测血小板内皮型一氧化氮合酶（eNOS）活性。
与HCs相比，MD患者的血浆NOx水平和血小板eNOS活性均显著降低。
这些数据表明，血管壁和血小板的NO生成减少可能导致MD患者冠心病风险增加。
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