Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Departments of Psychiatry, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
BMC Anesthesiol. 2022 May 26;22(1):163. doi: 10.1186/s12871-022-01686-6.
This study explored the patient clinical characteristics that may affect electroconvulsive therapy (ECT) efficacy to enable improved focus during evaluations and preparation for ECT.
Patients were enrolled for ECT at the Department of Psychiatry and Anesthesiology of the First Affiliated Hospital of Chongqing Medical University from December 2017 to January 2019. The primary outcome in our study was defined as the development of nonremission. A multivariate logistic analysis was performed to identify the risk factors for nonremission.
In total, 874 depressed patients were included in the study. After the ECT treatment, 255 cases (29.2%) exhibited nonremission. A multivariate logistic regression analysis of the variables was performed, and the results showed that atherosclerosis (OR 8.072, 95% CI 2.442 to 16.675; P = 0.001), COPD (OR 2.919, 95% CI 1.240 to 6.871; P = 0.014), diabetes (OR 2.202, 95% CI 1.115 to 4.348; P = 0.023) and smoking (OR 1.519, 95% CI 1.015 to 2.273; P = 0.042) were independent risk factors for nonremission.
In the retrospective analysis, we found that atherosclerosis, diabetes, COPD and smoking may be high-risk factors for nonremission.
本研究旨在探讨可能影响电抽搐治疗（ECT）疗效的患者临床特征，以便在评估和准备 ECT 时能够更有针对性。
2017 年 12 月至 2019 年 1 月，患者在重庆医科大学第一附属医院精神科和麻醉科接受 ECT。本研究的主要结局定义为无缓解的发生。采用多变量逻辑分析来确定无缓解的危险因素。
共纳入 874 例抑郁患者。ECT 治疗后，255 例（29.2%）患者无缓解。对变量进行多变量逻辑回归分析，结果显示，动脉粥样硬化（OR 8.072，95%CI 2.442 至 16.675；P=0.001）、COPD（OR 2.919，95%CI 1.240 至 6.871；P=0.014）、糖尿病（OR 2.202，95%CI 1.115 至 4.348；P=0.023）和吸烟（OR 1.519，95%CI 1.015 至 2.273；P=0.042）是无缓解的独立危险因素。
在回顾性分析中，我们发现动脉粥样硬化、糖尿病、COPD 和吸烟可能是无缓解的高危因素。
