疟疾中的血小板减少症。

Thrombocytopenia in malaria.

作者信息

Looareesuwan S, Davis J G, Allen D L, Lee S H, Bunnag D, White N J

机构信息

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1992 Mar;23(1):44-50.

PMID:1523477

Abstract

The relationship between platelet counts and platelet bound (direct) or platelet directed (indirect) serum antibody concentrations was studied in 17 patients with Plasmodium falciparum malaria and 12 patients with P. vivax malaria. Platelet counts rose with recovery from infection from 196 +/- 84 x 10(9)/l (mean +/- SD) and 195 +/- 34 x 10(9)/l to 319 +/- 99 and 283 +/- 62 x 10(9)/l respectively (p less than 0.002), but there was no relationship between either absolute platelet count or changes in counts and either indirect or direct platelet antibody levels. These findings suggest that a non-immunologically mediated mechanism is involved in the pathogenesis of thrombocytopenia in malaria.

摘要

对17例恶性疟患者和12例间日疟患者的血小板计数与血小板结合（直接）或血小板导向（间接）血清抗体浓度之间的关系进行了研究。随着感染的恢复，血小板计数从196±84×10⁹/l（平均值±标准差）和195±34×10⁹/l分别升至319±99和283±62×10⁹/l（p<0.002），但绝对血小板计数或计数变化与间接或直接血小板抗体水平之间均无关系。这些发现提示，非免疫介导机制参与了疟疾血小板减少的发病过程。