间日疟患儿的血小板减少症：一项来自印度北部的研究。

Thrombocytopenia in children with vivax malaria: a study from north India.

作者信息

Kumar Chandra Mohan, Singh Shweta, Garg Rajnish

机构信息

Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, 110029, India,

出版信息

Indian J Pediatr. 2014 Mar;81(3):266-9. doi: 10.1007/s12098-013-1277-3. Epub 2013 Dec 11.

DOI:10.1007/s12098-013-1277-3

PMID:24327084

Abstract

OBJECTIVES

To study incidence, severity and clinical significance of thrombocytopenia and to study recovery pattern of platelet counts in children with vivax malaria.

METHODS

This was a retrospective hospital based descriptive case series. Cases of confirmed vivax malaria were studied and their Total Platelet Counts (TPC) evaluated daily till recovery and again after 1 wk on follow up visit.

RESULTS

In this study out of 39 children of confirmed vivax malaria 22 had thrombocytopenia, having mean platelet count 48 × 10(9)/L on admission which showed a very quick recovery on treatment and by day 3 of treatment it rose to 126.5 × 10(9)/L without platelet transfusion. In untreated cases the lowest platelet counts was observed on day 5-6 and on treatment, platelet counts returned to normal without any platelet transfusion by 9th day. Even among children there are variations in different age groups and younger ones show more quicker recovery than older peers.

CONCLUSIONS

Vivax malaria is associated with transient thrombocytopenia which does not lead to significant bleeding in children.

摘要

目的

研究间日疟患儿血小板减少症的发生率、严重程度及临床意义，并研究血小板计数的恢复模式。

方法

这是一项基于医院的回顾性描述性病例系列研究。对确诊为间日疟的病例进行研究，每天评估其血小板总数（TPC），直至恢复，并在随访1周后再次评估。

结果

在本研究中，39例确诊为间日疟的儿童中，22例有血小板减少症，入院时平均血小板计数为48×10⁹/L，治疗后恢复很快，治疗第3天升至126.5×10⁹/L，无需输注血小板。在未治疗的病例中，血小板计数最低出现在第5 - 6天，治疗后，到第9天血小板计数恢复正常，无需任何血小板输注。即使在儿童中，不同年龄组也存在差异，年幼者比年长者恢复得更快。