采用高效液相色谱法对替罗普胺进行对映体拆分。
Enantioseparation of tiropramide by HPLC.
作者信息
Ryoo Jae Jeong, Heo Kyu Sung, Choi Eun-Soon, Park Jung Hag, Lee Wonjae
机构信息
Department of Chemistry, Graduate School, Kyungpook National University, 702-701 Daegu, Korea.
出版信息
Chirality. 2004;16 Suppl:S51-4. doi: 10.1002/chir.20050.
PMID:15239073
Abstract
Tiropramide is an antispasmodic drug that has a chiral center. Resolution of tiropramide enantiomers on various kinds of chiral stationary phases was performed by HPLC. A good resolution on a leucine-derived chiral stationary phase was found. An improved chromatographic condition to resolve racemic tiropramide on the CSP was examined by changing the flow rate, composition, and kind of mobile phases.
摘要
替罗酰胺是一种具有手性中心的解痉药。采用高效液相色谱法在各种手性固定相上拆分替罗酰胺对映体。结果发现，在亮氨酸衍生的手性固定相上有良好的拆分效果。通过改变流动相的流速、组成和种类，研究了在该手性固定相上拆分外消旋替罗酰胺的改进色谱条件。
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