血管性痴呆患者脑脊液中白细胞介素-6水平升高。
Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients.
作者信息
Wada-Isoe K, Wakutani Y, Urakami K, Nakashima K
机构信息
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan.
出版信息
Acta Neurol Scand. 2004 Aug;110(2):124-7. doi: 10.1111/j.1600-0404.2004.00286.x.
OBJECTIVES
To investigate a possible implication of inflammatory processes in the development of dementia in cerebrovascular disease.
PATIENTS AND METHODS
We examined the levels of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD) (n = 26), ischemic cerebrovascular disease without dementia (CVD) (n = 11), vascular dementia (VD) (n = 11), and other neurological disorders (n = 21) using sensitive enzyme-linked immunosorbent assay.
RESULTS
The CSF concentrations of IL-6 were significantly elevated in patients with VD compared with those of patients with AD or CVD.
CONCLUSION
The CSF IL-6 levels are increased in patients with VD, suggesting that inflammatory mechanisms may be involved in the development of cognitive decline in some patients with cerebrovascular disease. CSF IL-6 may be a biological marker for dementia in cerebrovascular disease.
目的
探讨炎症过程在脑血管疾病所致痴呆发生中的可能作用。
患者与方法
我们采用灵敏的酶联免疫吸附测定法，检测了阿尔茨海默病（AD）患者（n = 26）、无痴呆的缺血性脑血管疾病（CVD）患者（n = 11）、血管性痴呆（VD）患者（n = 11）以及其他神经系统疾病患者（n = 21）脑脊液（CSF）中白细胞介素-6（IL-6）的水平。
结果
与AD或CVD患者相比，VD患者脑脊液中IL-6浓度显著升高。
结论
VD患者脑脊液IL-6水平升高，提示炎症机制可能参与了部分脑血管疾病患者认知功能下降的发生过程。脑脊液IL-6可能是脑血管疾病所致痴呆的一个生物学标志物。
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