Mensi Magda, Salgarello Stefano, Pinsi Gabriele, Piccioni Michela
Department of Endodontology and Oral Surgery, University of Brescia Dental School, Piazzale Spedali Civili No. 1, 25123 Brescia, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Jul;98(1):119-23. doi: 10.1016/j.tripleo.2003.12.035.
The purpose was to show the capacity of zinc oxide and eugenol to affect the growth of Aspergillus fumigatus.
An in vitro microbiological analysis was conducted on samples from infected maxillary sinuses and on 3 different endodontic sealers.
Tests showed that zinc oxide in solution favors the growth of Aspergillus fumigatus, while eugenol inhibits this growth, even when mixed with zinc oxide powder. This inhibiting effect decreases over time. A reduced effectiveness was demonstrated over a 75-day period.
The hypothesis is that the diminishing concentration of eugenol over time in endodontic sealers allows the zinc oxide to support growth of Aspergillus fumigatus. This is reinforced by clinical experience, where mycetoma has developed years after endodontic therapy with excess sealer in the maxillary sinus.