硬皮病与紫杉烷类。真的存在关联吗？

Scleroderma and the taxanes. Is there really a link?

作者信息

Farrant P B J, Mortimer P S, Gore M

机构信息

Department of Dermatology, St George's Hospital, The Royal Marsden Hospital, London, UK.

出版信息

Clin Exp Dermatol. 2004 Jul;29(4):360-2. doi: 10.1111/j.1365-2230.2004.01519.x.

DOI:10.1111/j.1365-2230.2004.01519.x

PMID:15245529

Abstract

Scleroderma has been associated with exposure to many substances in the past ranging from vinyl chloride to silicon dioxide. In recent years there have been a number of case reports linking modern chemotherapy agents, such as the taxanes to the development of scleroderma like changes. We present a further case of scleroderma in association with chemotherapy but question the role of some of the agents previously implicated. A brief review of the current literature is included.

摘要

过去，硬皮病与接触多种物质有关，从氯乙烯到二氧化硅。近年来，有许多病例报告将现代化疗药物，如紫杉烷类药物与硬皮病样改变的发生联系起来。我们报告了一例与化疗相关的硬皮病病例，但对一些先前被认为有牵连的药物的作用提出质疑。文中还包括对当前文献的简要综述。