使用紫杉醇治疗卵巢癌后发生的弥漫性硬皮病。

Diffuse scleroderma occurring after the use of paclitaxel for ovarian cancer.

作者信息

De Angelis R, Bugatti L, Cerioni A, Del Medico P, Filosa G

机构信息

Ospedale Augusto Murri, via dei Colli 52, 60035 Jesi, Ancona, Italy.

出版信息

Clin Rheumatol. 2003 Feb;22(1):49-52. doi: 10.1007/s10067-002-0635-8.

DOI:10.1007/s10067-002-0635-8

PMID:12605319

Abstract

Acase of diffuse scleroderma in a 56-year-old woman who received paclitaxel for the treatment of a metastatic ovarian cancer is presented. The clinical cutaneous alterations, as well as the capillaroscopic and histological findings, were indistinguishable from those encountered in definite systemic sclerosis (SSc). In contrast to SSc, Raynaud's phenomenon and cutaneous calcinosis were absent and antinuclear antibodies were negative. The temporal relationship between the onset of skin involvement and administration of the drug may indicate an effect of paclitaxel.

摘要

本文报告了一例56岁女性弥漫性硬皮病病例，该患者因转移性卵巢癌接受紫杉醇治疗。临床皮肤改变、毛细血管镜检查及组织学检查结果与确诊的系统性硬化症（SSc）难以区分。与SSc不同的是，该患者无雷诺现象和皮肤钙化，抗核抗体阴性。皮肤受累发作与药物给药之间的时间关系可能提示紫杉醇的作用。