（E）-和（Z）-1,2,4-三唑基苯并二氢吡喃酮肟醚作为构象受限的抗真菌剂。
(E)- and (Z)-1,2,4-triazolylchromanone oxime ethers as conformationally constrained antifungals.
作者信息
Emami Saeed, Falahati Mehraban, Banifatemi Ali, Amanlou Massoud, Shafiee Abbas
机构信息
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, PO Box 48175-861, Sari, Iran.
出版信息
Bioorg Med Chem. 2004 Aug 1;12(15):3971-6. doi: 10.1016/j.bmc.2004.06.010.
PMID:15246073
Abstract
A series of 1,2,4-triazolylchromanone oxime ethers were synthesized and tested for in vitro antifungal activity. Many of these derivatives exhibit high activity against Candida albicans, Saccharomyces cerevisiae, Aspergillus niger and Microsporum gypseum.
摘要
合成了一系列1,2,4-三唑基色满酮肟醚，并对其体外抗真菌活性进行了测试。这些衍生物中的许多对白色念珠菌、酿酒酵母、黑曲霉和石膏样小孢子菌表现出高活性。
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