Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Jurasza Str. 2, 85-089 Bydgoszcz, Poland.
Department of Medical Biology and Biochemistry, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Karłowicza Str. 24, 85-092 Bydgoszcz, Poland.
Molecules. 2023 Jun 28;28(13):5041. doi: 10.3390/molecules28135041.
Oxime ethers are a class of compounds containing the >C=N-O-R moiety. The presence of this moiety affects the biological activity of the compounds. In this review, the structures of oxime ethers with specific biological activity have been collected and presented, and bactericidal, fungicidal, antidepressant, anticancer and herbicidal activities, among others, are described. The review includes both those substances that are currently used as drugs (e.g., fluvoxamine, mayzent, ridogrel, oxiconazole), as well as non-drug structures for which various biological activity studies have been conducted. To the best of our knowledge, this is the first review of the biological activity of compounds containing such a moiety. The authors hope that this review will inspire scientists to take a greater interest in this group of compounds, as it constitutes an interesting research area.
肟醚是一类含有 >C=N-O-R 部分的化合物。该部分的存在会影响化合物的生物活性。在本次综述中，收集并展示了具有特定生物活性的肟醚的结构，并描述了杀菌、杀菌、抗抑郁、抗癌和除草等活性。本综述既包括了目前用作药物的物质（如氟伏沙明、美金刚、利格列汀、奥昔康唑），也包括了进行了各种生物活性研究的非药物结构。据我们所知，这是对含有这种部分的化合物的生物活性的首次综述。作者希望这篇综述能激发科学家对这一类化合物产生更大的兴趣，因为它构成了一个有趣的研究领域。
