白细胞计数与脑血管疾病死亡率风险之间的关联：美国国家健康与营养检查调查II死亡率研究，1976 - 1992年

Associations between white blood cell count and risk for cerebrovascular disease mortality: NHANES II Mortality Study, 1976-1992.

作者信息

Brown David W, Ford Earl S, Giles Wayne H, Croft Janet B, Balluz Lina S, Mokdad Ali H

机构信息

Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.

出版信息

Ann Epidemiol. 2004 Jul;14(6):425-30. doi: 10.1016/j.annepidem.2003.11.002.

DOI:10.1016/j.annepidem.2003.11.002

PMID:15246331

Abstract

PURPOSE

To examine associations between elevated white blood cell count (WBC) and cerebrovascular disease (CeVD) mortality independent of cigarette smoking and by gender.

METHODS

We used Cox regression analyses of data from 8459 adults (3982 men; 4477 women) aged 30 to 75 years in the NHANES II Mortality Study (1976-1992) to estimate the relative risk of death from CeVD across quartiles of WBC.

RESULTS

During 17 years of follow-up, there were 192 deaths from CeVD (93 men; 99 women). Compared with those with WBC (cells/mm(3))<5700, adults with WBC>8200 were at increased risk of CeVD mortality (relative risk [RR], 2.1; 95% confidence interval [CI], 1.2-3.7) after adjustment for smoking and other cardiovascular disease risk factors. Similar results were observed among never smokers (RR, 2.0; 95% CI, 1.0-3.8). The adjusted relative risk of CeVD mortality comparing those with WBC>8200 to those with WBC<5700 was 1.5 (95% CI, 0.7-3.5) among men and 2.7 (95% CI, 1.4-5.0) among women.

CONCLUSIONS

Elevated WBC may predict CeVD mortality even after considering the effects of smoking and other cardiovascular disease risk factors.

摘要

目的

探讨白细胞计数（WBC）升高与脑血管疾病（CeVD）死亡率之间的关联，且该关联独立于吸烟因素并按性别进行分析。

方法

我们对国家健康和营养检查调查II死亡率研究（1976 - 1992年）中8459名年龄在30至75岁的成年人（3982名男性；4477名女性）的数据进行Cox回归分析，以估计CeVD死亡风险在WBC四分位数间的相对风险。

结果

在17年的随访期间，有192例CeVD死亡（93名男性；99名女性）。与WBC（细胞/立方毫米）<5700的成年人相比，在调整吸烟和其他心血管疾病风险因素后，WBC>8200的成年人CeVD死亡风险增加（相对风险[RR]，2.1；95%置信区间[CI]，1.2 - 3.7）。在从不吸烟者中也观察到类似结果（RR，2.0；95% CI，1.0 - 3.8）。将WBC>8200者与WBC<5700者相比，调整后的CeVD死亡相对风险在男性中为1.5（95% CI，0.7 - 3.5），在女性中为2.7（95% CI，1.4 - 5.0）。