整合酶抑制剂和细胞免疫可抑制恒河猴体内的逆转录病毒复制。
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques.
作者信息
Hazuda Daria J, Young Steven D, Guare James P, Anthony Neville J, Gomez Robert P, Wai John S, Vacca Joseph P, Handt Larry, Motzel Sherri L, Klein Hilton J, Dornadula Geethanjali, Danovich Robert M, Witmer Marc V, Wilson Keith A A, Tussey Lynda, Schleif William A, Gabryelski Lori S, Jin Lixia, Miller Michael D, Casimiro Danilo R, Emini Emilio A, Shiver John W
机构信息
Department of Biological Chemistry, Merck Research Laboratories, Post Office Box 4, West Point, PA 19486, USA.
出版信息
Science. 2004 Jul 23;305(5683):528-32. doi: 10.1126/science.1098632. Epub 2004 Jul 8.
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained suppression of viremia, preserving CD4 levels and permitting the induction of virus-specific cellular immunity. L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. These studies demonstrate integrase inhibitor activity in vivo and suggest that cellular immunity facilitates chemotherapeutic efficacy in retroviral infections.
我们描述了HIV-1和SIV整合酶抑制剂L-870812在感染猿猴-人类免疫缺陷病毒（SHIV）89.6P的恒河猴中的疗效。在CD4细胞耗竭之前开始使用L-870812治疗，可介导病毒血症的持续抑制，维持CD4水平，并诱导病毒特异性细胞免疫。L-870812在慢性感染中也具有活性；然而，其效果的程度和持久性随预处理免疫反应和病毒载量而变化。这些研究证明了整合酶抑制剂在体内的活性，并表明细胞免疫促进了逆转录病毒感染中的化疗疗效。
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