肾上腺素的光稳定性——亚硫酸氢盐和降解产物的影响

Photostability of epinephrine - the influence of bisulfite and degradation products.

作者信息

Brustugun J, Kristensen S, Tønnesen H Hjorth

机构信息

School of Pharmacy, Department of Pharmaceutics, University of Oslo, Norway.

出版信息

Pharmazie. 2004 Jun;59(6):457-63.

PMID:15248461

Abstract

Sulfites are previously demonstrated to increase the photodegradation of epinephrine. The aim of this study was to clarify the factors responsible for this effect. Adrenochrome sulfonate seems to be the important substance. Photoproduction of singlet oxygen is indicated to be the mechanism by which adrenochrome sulfonate acts. Protection of epinephrine solutions from irradiation <418 nm prevented the photodegradation. A reaction pathway for thephotochemical decomposition of epinephrine in the presence of bisulfite is suggested.

摘要

亚硫酸盐先前已被证明会增加肾上腺素的光降解。本研究的目的是阐明造成这种效应的因素。肾上腺色素磺酸盐似乎是重要物质。单线态氧的光生成被认为是肾上腺色素磺酸盐起作用的机制。将肾上腺素溶液避光（波长<418 nm）可防止光降解。本文提出了在亚硫酸氢盐存在下肾上腺素光化学分解的反应途径。