光化学诱导肾上腺色素向肾上腺色素-黑色素的转化。

Photochemically induced transformation of adrenochrome to adrenochrome-melanin.

作者信息

Polewiski K, Slawinska D

机构信息

Department of Physics, Agricultural University, Poznan, Poland.

出版信息

Physiol Chem Phys Med NMR. 1991;23(2):125-32.

PMID:1946698

Abstract

The photochemical decomposition of adrenochrome in aqueous and deuterated solutions by visible light was investigated. From the spectroscopic study the disappearance constant k = 4.8 x 10(-5) s-1 as well as quenching constant kq = 2.5 x 10(-1) [s M-1] and isotope effect kD/kH = 2 for singlet oxygen mechanism have been calculated. A possible chemical mechanism for the observed transformation of adrenochrome to the melanin polymer is discussed including the formation of the reactive intermediate species like cytotoxic quinones.

摘要

研究了可见光作用下肾上腺色素在水溶液和重水溶液中的光化学分解。通过光谱研究，计算出单线态氧机制的消失常数k = 4.8×10⁻⁵ s⁻¹、猝灭常数kq = 2.5×10⁻¹ [s M⁻¹]以及同位素效应kD/kH = 2。讨论了观察到的肾上腺色素向黑色素聚合物转化的可能化学机制，包括细胞毒性醌等反应性中间物种的形成。