双氯芬酸有机锡配合物的制备及光谱研究
Preparations and spectroscopic studies of organotin complexes of diclofenac.
作者信息
Kourkoumelis Nikolaos, Demertzis Mavroudis A, Kovala-Demertzi Dimitra, Koutsodimou Aglaia, Moukarika Alice
机构信息
Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45100 Ioannina, Greece.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2004 Aug;60(10):2253-9. doi: 10.1016/j.saa.2003.11.027.
The reactions of the potent and widely used anti-inflammatory drug diclofenac, HL, with diorganotin(IV) oxides were studied. The dimeric tetraorganodistannoxane complexes Me(2)LSnOSnLMe(2), Bu(2)LSnOSnLBu(2), Ph(2)LSnOSnLPh(2) and the dibutyltin complex [Bu(2)SnL(2)], have been prepared and structurally characterized in the solid state by means of vibrational and 119Sn Mössbauer spectroscopy. Determination of lattice dynamics by temperature-dependent 119Sn Mössbauer spectroscopy. From the variable-temperature Mössbauer effect, the Debye temperature was determined. The complexes have been characterized in solution by NMR (1H and 13C) spectroscopy. Vibrational, Mössbauer, and NMR data are discussed in terms of the proposed structures.
研究了强效且广泛使用的抗炎药物双氯芬酸（HL）与二有机锡（IV）氧化物的反应。制备了二聚四有机二锡氧烷配合物Me(2)LSnOSnLMe(2)、Bu(2)LSnOSnLBu(2)、Ph(2)LSnOSnLPh(2)以及二丁基锡配合物[Bu(2)SnL(2)]，并通过振动光谱和119Sn穆斯堡尔光谱对其固态结构进行了表征。通过变温119Sn穆斯堡尔光谱测定晶格动力学。根据变温穆斯堡尔效应确定了德拜温度。通过核磁共振（1H和13C）光谱对配合物在溶液中的性质进行了表征。根据所提出的结构对振动、穆斯堡尔和核磁共振数据进行了讨论。
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