与使用氟哌啶醇相比，接受利培酮和奥氮平治疗的老年患者死亡率更低：回顾性数据的初步分析
Lower mortality in geriatric patients receiving risperidone and olanzapine versus haloperidol: preliminary analysis of retrospective data.
作者信息
Nasrallah Henry A, White Thantween, Nasrallah Amelia T
机构信息
Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA.
出版信息
Am J Geriatr Psychiatry. 2004 Jul-Aug;12(4):437-9. doi: 10.1176/appi.ajgp.12.4.437.
OBJECTIVE
The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics.
METHODS
Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254).
RESULTS
Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant.
CONCLUSIONS
The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.
目的
作者研究了接受氟哌啶醇或非典型抗精神病药物治疗的老年患者的死亡率。
方法
作者对年龄在65岁及以上、接受氟哌啶醇治疗的患者（N = 299）或接受非典型抗精神病药物利培酮或奥氮平治疗的患者（N = 1254）进行了为期2年的死亡率跟踪。
结果
在为期2年的研究期间，氟哌啶醇组有64名患者（21.4%）死亡，非典型药物组有61名患者（4.75%）死亡。差异具有统计学意义。
结论
研究结果表明，接受氟哌啶醇治疗的老年患者的死亡率显著高于接受非典型抗精神病药物利培酮或奥氮平治疗的患者。作者讨论了可能的因果机制。
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