Rojas Maria C, Lumba Joanna D, Manche Edward E
Department of Ophthalmology, Stanford University School of Medicine, Stanford, Calif. 94305, USA.
Arch Ophthalmol. 2004 Jul;122(7):997-1001. doi: 10.1001/archopht.122.7.997.
To evaluate the efficacy and safety of mechanical debridement and suturing of the laser in situ keratomileusis (LASIK) flap in the treatment of clinically significant epithelial ingrowth after LASIK.
In a retrospective study, 20 eyes (n = 19 patients) in which clinically significant epithelial ingrowth developed after LASIK were treated with lifting of the flap, scraping of the epithelial ingrowth, and flap suturing. Primary outcome measurements including recurrence of ingrowth, uncorrected visual acuity (VA), manifest refraction, best spectacle-corrected VA, and complications were evaluated at the last postoperative examination.
At the last postoperative examination (mean +/- SD, 10.5 +/- 14.3 months; range, 1.5-64 months), 100% of eyes had no recurrence of clinically significant epithelial ingrowth. The uncorrected VA changed from 20/20 or better in 7 eyes (35%) and 20/40 or better in 15 eyes (75%) preoperatively to 20/20 or better in 9 eyes (45%) and 20/40 or better in 16 eyes (80%) at the last follow-up examination. There was no significant change in the mean logarithm of the minimum angle of resolution (logMAR) uncorrected VA before (mean +/- SD, 0.3 +/- 0.5; range, -0.1 to 1.7) and after surgery (mean +/- SD, 0.2 +/- 0.4; range, -0.1 to 1.7) (P =.40). Mean +/- SD spherical equivalent changed from -0.21 +/- 0.82 diopters (D) (range, -1.25 to 1.00 D) preoperatively to -0.53 +/- 0.89 D (range, -2.50 to 0.38 D) at last follow-up (P =.30). No eyes lost 2 or more lines of best spectacle-corrected VA, and there were no complications associated with the treatment.
Suturing the LASIK flap in addition to mechanical debridement of epithelial ingrowth is a safe and effective treatment for clinically significant epithelial ingrowth after LASIK.
评估准分子原位角膜磨镶术(LASIK)瓣机械清创及缝合在治疗LASIK术后具有临床意义的上皮植入方面的疗效和安全性。
在一项回顾性研究中,对20只眼(19例患者)进行治疗,这些眼在LASIK术后出现了具有临床意义的上皮植入,采用掀起瓣、刮除上皮植入物及瓣缝合的方法。在最后一次术后检查时评估主要结局指标,包括植入复发、裸眼视力(VA)、显验光、最佳矫正视力及并发症。
在最后一次术后检查时(平均±标准差,10.5±14.3个月;范围,1.5 - 64个月),100%的眼无具有临床意义的上皮植入复发。裸眼视力从术前7只眼(35%)为20/20或更好、15只眼(75%)为20/40或更好,变为最后一次随访检查时9只眼(45%)为20/20或更好、16只眼(80%)为20/40或更好。术前(平均±标准差,0.3±0.5;范围,-0.1至1.7)和术后(平均±标准差,0.2±0.4;范围,-0.1至1.7)最小分辨角对数(logMAR)裸眼视力无显著变化(P = 0.40)。平均±标准差等效球镜度从术前的-0.21±0.82屈光度(D)(范围,-1.25至1.00 D)变为最后一次随访时的-0.53±0.89 D(范围,-2.50至0.38 D)(P = 0.30)。没有眼的最佳矫正视力下降2行或更多,且治疗无相关并发症。
除了对上皮植入进行机械清创外,缝合LASIK瓣是治疗LASIK术后具有临床意义的上皮植入的一种安全有效的方法。