Segerstrom Suzanne C, Miller Gregory E
Department of Psychology, University of Kentucky, Lexington, KY 40506, USA.
Psychol Bull. 2004 Jul;130(4):601-30. doi: 10.1037/0033-2909.130.4.601.
The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants. Acute stressors (lasting minutes) were associated with potentially adaptive upregulation of some parameters of natural immunity and downregulation of some functions of specific immunity. Brief naturalistic stressors (such as exams) tended to suppress cellular immunity while preserving humoral immunity. Chronic stressors were associated with suppression of both cellular and humoral measures. Effects of event sequences varied according to the kind of event (trauma vs. loss). Subjective reports of stress generally did not associate with immune change. In some cases, physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.
本报告对300多篇实证文章进行了荟萃分析,这些文章描述了心理压力与人类参与者免疫系统参数之间的关系。急性应激源(持续数分钟)与自然免疫的某些参数潜在适应性上调以及特异性免疫的某些功能下调有关。短暂的自然应激源(如考试)往往会抑制细胞免疫,同时保留体液免疫。慢性应激源与细胞免疫和体液免疫指标的抑制有关。事件序列的影响因事件类型(创伤与损失)而异。压力的主观报告通常与免疫变化无关。在某些情况下,作为年龄或疾病函数的身体易感性也会增加在应激源期间免疫变化的易感性。