血液透析患者的肺部钙化：与肺动脉压值的相关性
Pulmonary calcification in hemodialysis patients: correlation with pulmonary artery pressure values.
作者信息
Yigla Mordechai, Keidar Zohar, Safadi Isra, Tov Naveh, Reisner Shimon A, Nakhoul Farid
机构信息
Division of Pulmonary Medicine, Rambam Medical Center and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
出版信息
Kidney Int. 2004 Aug;66(2):806-10. doi: 10.1111/j.1523-1755.2004.00807.x.
BACKGROUND
End-stage renal disease (ESRD) patients receiving chronic hemodialysis (HD) via an arteriovenous (A-V) access often develop unexplained pulmonary hypertension (PHT). This study evaluated the role of pulmonary calcification (PC) in this phenomenon.
METHODS
The clinical manifestations, systolic pulmonary artery pressure (PAP) values measured by Doppler echocardiography and the presence and the extent of PC expressed by lung uptake of 99mTc-MDP bone scintigraphy, were studied in 49 patients with ESRD receiving chronic HD therapy via A-V access. The correlation between PC and PHT was investigated.
RESULTS
There were 36 men and 13 women with a mean age of 61.7 +/- 13.2 years receiving HD therapy for 38.2 +/- 43.7 months. Twenty (40.8%) patients had PC expressed by increased lung uptake of 99mTc- MDP and 28 (57.1%) patients had PHT with a mean systolic PAP of 46 +/- 11 mm Hg. No correlation was found between PC and PHT.
CONCLUSION
The data suggest that PC expressed by lung uptake of 99mTc-MDP has no role in the pathogenesis of PHT among ESRD patients undergoing HD therapy via A-V access.
背景
接受动静脉内瘘慢性血液透析（HD）的终末期肾病（ESRD）患者常出现不明原因的肺动脉高压（PHT）。本研究评估了肺钙化（PC）在此现象中的作用。
方法
对49例通过动静脉内瘘接受慢性HD治疗的ESRD患者的临床表现、通过多普勒超声心动图测量的收缩期肺动脉压（PAP）值以及通过99mTc-MDP骨闪烁显像肺摄取所表达的PC的存在情况和程度进行了研究。研究了PC与PHT之间的相关性。
结果
36例男性和13例女性，平均年龄61.7±13.2岁，接受HD治疗38.2±43.7个月。20例（40.8%）患者通过99mTc-MDP肺摄取增加表现为PC，28例（57.1%）患者患有PHT，平均收缩期PAP为46±11 mmHg。未发现PC与PHT之间存在相关性。
结论
数据表明，通过99mTc-MDP肺摄取所表达的PC在接受动静脉内瘘HD治疗的ESRD患者PHT的发病机制中不起作用。
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