单纯疱疹病毒1型的病毒体宿主关闭蛋白在原代神经元中具有RNA降解活性。
The virion host shutoff protein of herpes simplex virus type 1 has RNA degradation activity in primary neurons.
作者信息
Strand Stephanie S, Vanheyningen Tambryn K, Leib David A
机构信息
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
出版信息
J Virol. 2004 Aug;78(15):8400-3. doi: 10.1128/JVI.78.15.8400-8403.2004.
Abstract
The virion host shutoff protein (Vhs) of herpes simplex virus type 1 induces destabilization of mRNA following infection. Our study of primary neurons from CD-1 mice demonstrates that vhs is functional in neurons but that more Vhs is required to mediate RNA degradation in neurons than in other susceptible cells.
摘要
单纯疱疹病毒1型的病毒体宿主关闭蛋白（Vhs）在感染后会诱导mRNA的不稳定。我们对CD-1小鼠原代神经元的研究表明，Vhs在神经元中具有功能，但与其他易感细胞相比，介导神经元中RNA降解需要更多的Vhs。
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