单纯疱疹病毒1型UL41保守结构域在病毒体宿主关闭及发病机制中的分析
Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis.
作者信息
Strelow L I, Leib D A
机构信息
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
出版信息
J Virol. 1996 Aug;70(8):5665-7. doi: 10.1128/JVI.70.8.5665-5667.1996.
Abstract
The herpes simplex virus type 1 virion host shutoff protein has four domains whose sequences are conserved only among neurotropic herpesviruses. Mutant viruses with 29- and 31-amino-acid deletions in domains III and IV but outside of the domain required for interaction with VP16 were generated. The mutants failed to induce cellular RNA degradation and showed impaired virulence in mice. Domains III and IV are therefore required for both shutoff and virulence.
摘要
单纯疱疹病毒1型病毒体宿主关闭蛋白有四个结构域，其序列仅在嗜神经疱疹病毒中保守。构建了在结构域III和IV中但在与VP16相互作用所需结构域之外有29个和31个氨基酸缺失的突变病毒。这些突变体未能诱导细胞RNA降解，并且在小鼠中显示出毒力受损。因此，结构域III和IV对于关闭和毒力都是必需的。
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1
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J Virol. 1996 Apr;70(4):2411-9. doi: 10.1128/JVI.70.4.2411-2419.1996.
2
Identification and characterization of a small modular domain in the herpes simplex virus host shutoff protein sufficient for interaction with VP16.单纯疱疹病毒宿主关闭蛋白中一个足以与VP16相互作用的小模块化结构域的鉴定与表征。
J Virol. 1996 Apr;70(4):2124-31. doi: 10.1128/JVI.70.4.2124-2131.1996.
3
The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts.伪狂犬病病毒宿主关闭同源基因：核苷酸序列及其与甲型疱疹病毒相应蛋白的比较。
Virology. 1993 Apr;193(2):1028-32. doi: 10.1006/viro.1993.1221.
4
Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.一株在病毒体宿主关闭基因中有缺失的单纯疱疹病毒1型突变体的分离以及病毒宿主关闭蛋白（UL41）多肽多种形式的鉴定。
J Virol. 1993 Dec;67(12):7149-60. doi: 10.1128/JVI.67.12.7149-7160.1993.
5
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J Virol. 1994 Apr;68(4):2339-46. doi: 10.1128/JVI.68.4.2339-2346.1994.
6
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Virology. 1995 Aug 20;211(2):491-506. doi: 10.1006/viro.1995.1431.
7
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Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides.单纯疱疹病毒突变体在病毒体相关的宿主多肽合成关闭方面存在缺陷，并表现出α（立即早期）病毒多肽的异常合成。
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