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单纯疱疹病毒1型UL41保守结构域在病毒体宿主关闭及发病机制中的分析

Analysis of conserved domains of UL41 of herpes simplex virus type 1 in virion host shutoff and pathogenesis.

作者信息

Strelow L I, Leib D A

机构信息

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

出版信息

J Virol. 1996 Aug;70(8):5665-7. doi: 10.1128/JVI.70.8.5665-5667.1996.

DOI:10.1128/JVI.70.8.5665-5667.1996
PMID:8764085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC190531/
Abstract

The herpes simplex virus type 1 virion host shutoff protein has four domains whose sequences are conserved only among neurotropic herpesviruses. Mutant viruses with 29- and 31-amino-acid deletions in domains III and IV but outside of the domain required for interaction with VP16 were generated. The mutants failed to induce cellular RNA degradation and showed impaired virulence in mice. Domains III and IV are therefore required for both shutoff and virulence.

摘要

单纯疱疹病毒1型病毒体宿主关闭蛋白有四个结构域，其序列仅在嗜神经疱疹病毒中保守。构建了在结构域III和IV中但在与VP16相互作用所需结构域之外有29个和31个氨基酸缺失的突变病毒。这些突变体未能诱导细胞RNA降解，并且在小鼠中显示出毒力受损。因此，结构域III和IV对于关闭和毒力都是必需的。

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本文引用的文献

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The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro.单纯疱疹病毒1型的病毒体宿主关闭蛋白：体外信使核糖核酸酶活性
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The pseudorabies virus host-shutoff homolog gene: nucleotide sequence and comparison with alphaherpesvirus protein counterparts.伪狂犬病病毒宿主关闭同源基因：核苷酸序列及其与甲型疱疹病毒相应蛋白的比较。
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Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide.一株在病毒体宿主关闭基因中有缺失的单纯疱疹病毒1型突变体的分离以及病毒宿主关闭蛋白（UL41）多肽多种形式的鉴定。
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Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.单纯疱疹病毒VP16与病毒体宿主关闭蛋白vhs形成复合物。
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The virion host shutoff protein of herpes simplex virus inhibits reporter gene expression in the absence of other viral gene products.单纯疱疹病毒的病毒体宿主关闭蛋白在不存在其他病毒基因产物的情况下会抑制报告基因的表达。
Virology. 1995 Aug 20;211(2):491-506. doi: 10.1006/viro.1995.1431.
7
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J Virol. 1995 Aug;69(8):4863-71. doi: 10.1128/JVI.69.8.4863-4871.1995.
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Role of the virion host shutoff (vhs) of herpes simplex virus type 1 in latency and pathogenesis.单纯疱疹病毒1型的病毒体宿主关闭蛋白（vhs）在潜伏和发病机制中的作用。
J Virol. 1995 Nov;69(11):6779-86. doi: 10.1128/JVI.69.11.6779-6786.1995.
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J Virol. 1983 May;46(2):498-512. doi: 10.1128/JVI.46.2.498-512.1983.
10
Early and delayed shut-off of host protein synthesis in cells infected with herpes simplex virus.单纯疱疹病毒感染细胞中宿主蛋白质合成的早期和延迟关闭
J Gen Virol. 1982 Jul;61 (Pt l):121-5. doi: 10.1099/0022-1317-61-1-121.