来自荜茇果实的酰基辅酶A：胆固醇酰基转移酶抑制剂——几内亚宁

Guineensine, an Acyl-CoA: cholesterol acyltransferase inhibitor, from the fruits of Piper longum.

作者信息

Lee Seung Woong, Rho Mun-Chual, Nam Jung Yeon, Lim Eun Hee, Kwon Oh Eok, Kim Young Ho, Lee Hyun Sun, Kim Young Kook

机构信息

Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-dong, Yusong-gu, Taejon 305-333, Korea.

出版信息

Planta Med. 2004 Jul;70(7):678-9. doi: 10.1055/s-2004-827193.

DOI:10.1055/s-2004-827193

PMID:15254860

Abstract

Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M.

摘要

针对酰基辅酶A胆固醇酰基转移酶（ACAT）抑制剂进行的生物活性导向分离，从荜茇的三氯甲烷提取物中分离出了几内亚苏碱。通过光谱手段（红外光谱、紫外光谱、质谱和核磁共振）确定了其结构。几内亚苏碱以剂量依赖性方式抑制ACAT活性，半数抑制浓度（IC50）值为3.12微摩尔。