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Isolation of Acyl-CoA:cholesterol acyltransferase inhibitor from Persicaria vulgaris.

作者信息

Song Hye Young, Rho Mun-Chual, Lee Seung Woong, Kwon Oh Eok, Chang Young-Duck, Lee Hyun Sun, Kim Young-Kook

机构信息

Cardiovascular Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.

出版信息

Planta Med. 2002 Sep;68(9):845-7. doi: 10.1055/s-2002-34395.

DOI:10.1055/s-2002-34395
PMID:12357403
Abstract

In the course of our search for Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from the methanol extract of Persicaria vulgaris. On the basis of spectral evidence, the structure of the active compound was identified as pheophorbide A. Pheophorbide A inhibited ACAT activity with an IC 50 value of 1.1 microg/ml in an enzyme assay using rat liver microsomes with a dose dependent fashion.

摘要

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