Loberg Robert D, Fridman Yaron, Pienta Brian A, Keller Evan T, McCauley Laurie K, Taichman Russell S, Pienta Kenneth J
Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0946, USA.
Neoplasia. 2004 Jul-Aug;6(4):302-9. doi: 10.1593/neo.03484.
The American Cancer Society has estimated that in 2003, there will be approximately 239,600 new cases of urologic cancer diagnosed and 54,600 urologic cancer-related deaths in the United States. To date, the majority of research and therapy design have focused on the microenvironment of the primary tumor site, as well as the microenvironment of the metastatic or secondary (target) tumor site. Little attention has been placed on the interactions of the circulating tumor cells and the microenvironment of the circulation (i.e., the third microenvironment). The purpose of this review is to present the methods for the detection and isolation of circulating tumor cells and to discuss the importance of circulating tumor cells in the biology and treatment of urologic cancers.
美国癌症协会估计,2003年美国将有大约239,600例新诊断的泌尿系统癌症病例,以及54,600例与泌尿系统癌症相关的死亡病例。迄今为止,大多数研究和治疗设计都集中在原发性肿瘤部位的微环境以及转移性或继发性(靶)肿瘤部位的微环境上。而对循环肿瘤细胞与循环微环境(即第三种微环境)之间的相互作用关注甚少。这篇综述的目的是介绍循环肿瘤细胞的检测和分离方法,并讨论循环肿瘤细胞在泌尿系统癌症生物学和治疗中的重要性。