来自东京巴豆（Croton tonkinensis Gagnep.）的四种对映-贝壳杉烷型二萜类化合物

Four ent-kaurane-type diterpenoids from Croton tonkinensis Gagnep.

作者信息

Giang Phan Minh, Son Phan Tong, Lee Jung Joon, Otsuka Hideaki

机构信息

Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi.

出版信息

Chem Pharm Bull (Tokyo). 2004 Jul;52(7):879-82. doi: 10.1248/cpb.52.879.

DOI:10.1248/cpb.52.879

PMID:15256715

Abstract

From the leaves of the endemic Vietnamese medicinal plant Croton tonkinensis GAGNEP. (Euphorbiaceae) the four new ent-kaurane-type diterpenoids ent-1alpha,14alpha-diacetoxy-7beta-hydroxykaur-16-en-15-one (1), ent-1alpha,7beta-diacetoxy-14alpha-hydroxykaur-16-en-15-one (2), ent-18-acetoxy-14alpha-hydroxykaur-16-en-15-one (3), and ent-(16S)-18-acetoxy-7beta-hydroxykauran-15-one (4) were isolated. Their structures were elucidated by spectroscopic analyses.

摘要

从越南本土药用植物东京巴豆（Croton tonkinensis GAGNEP.，大戟科）的叶子中分离出了四种新的对映-贝壳杉烷型二萜类化合物：对映-1α,14α-二乙酰氧基-7β-羟基贝壳杉-16-烯-15-酮（1）、对映-1α,7β-二乙酰氧基-14α-羟基贝壳杉-16-烯-15-酮（2）、对映-18-乙酰氧基-14α-羟基贝壳杉-16-烯-15-酮（3）和对映-(16S)-18-乙酰氧基-7β-羟基贝壳杉烷-15-酮（4）。通过光谱分析确定了它们的结构。