与急性期反应相关的铁调素表达增加和低铁血症不受HFE失活的影响。

Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE.

作者信息

Frazer David M, Wilkins Sarah J, Millard Kirstin N, McKie Andrew T, Vulpe Christopher D, Anderson Gregory J

机构信息

Iron Metabolism Laboratory, The Queensland Institute of Medical Research and The University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia.

出版信息

Br J Haematol. 2004 Aug;126(3):434-6. doi: 10.1111/j.1365-2141.2004.05044.x.

DOI:10.1111/j.1365-2141.2004.05044.x

PMID:15257718

Abstract

The effect of HFE inactivation on iron homeostasis during an acute phase response was investigated in mice. HFE knockout, beta2-microglobulin knockout and C57BL/6J mice were injected with Freund's Complete Adjuvant to induce an acute phase response and hepatic hepcidin expression and serum transferrin saturation was determined 16 h later. Hepcidin mRNA increased in all strains in response to an acute phase stimulus when compared with untreated control animals. Hypoferraemia also occurred in all strains, indicating that both the upregulation of hepcidin and the decrease in transferrin saturation associated with an acute phase response is not dependent on HFE function.

摘要

在小鼠中研究了HFE失活对急性期反应期间铁稳态的影响。给HFE基因敲除小鼠、β2-微球蛋白基因敲除小鼠和C57BL/6J小鼠注射弗氏完全佐剂以诱导急性期反应，并在16小时后测定肝脏铁调素表达和血清转铁蛋白饱和度。与未处理的对照动物相比，在所有品系中，急性期刺激均使铁调素mRNA增加。所有品系中也都出现了低铁血症，这表明与急性期反应相关的铁调素上调和转铁蛋白饱和度降低均不依赖于HFE功能。