Rivera Seth, Ganz Tomas
Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA.
Semin Hematol. 2009 Oct;46(4):351-7. doi: 10.1053/j.seminhematol.2009.06.003.
Anemia of inflammation (AI) is a complex multi-organ response to inflammatory disorders. Because AI can result from many infectious and non-infectious inflammatory diseases, multiple mechanisms may contribute to its pathogenesis, including iron restriction, direct erythropoietic suppression, shortened red blood cell survival, and frank hemolysis. Animal models have been helpful in the study of the mechanisms of AI and its potential treatments, but each model reflects distinct aspects of this heterogeneous syndrome. It is therefore important to study a variety of models of AI. This review focuses on the use of infectious and noninfectious mouse models of inflammation that have been shown to manifest anemia. We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks.
炎症性贫血（AI）是对炎症性疾病的一种复杂的多器官反应。由于AI可由多种感染性和非感染性炎症性疾病引起，其发病机制可能涉及多种机制，包括铁限制、直接的红细胞生成抑制、红细胞存活时间缩短以及明显的溶血。动物模型有助于研究AI的发病机制及其潜在治疗方法，但每种模型都反映了这种异质性综合征的不同方面。因此，研究多种AI模型很重要。本综述重点关注已被证明会出现贫血的感染性和非感染性小鼠炎症模型。我们回顾了文献中报道的或我们实验室开发的许多模型，并讨论了它们各自的优缺点。
