Ovesen T, Paaske P B, Elbroend O
Ear, Nose and Throat Department, Aarhus University Hospital, Denmark.
Clin Otolaryngol Allied Sci. 1992 Aug;17(4):327-31. doi: 10.1111/j.1365-2273.1992.tb01006.x.
The middle ears of patients with secretory otitis media treated by ventilation tubes are exposed to two abnormal conditions: an inflammatory process and a hyperoxic condition. Both are known to cause changes in the mucosa, fibrosis in particular. N-acetylcysteine has been demonstrated to exhibit anti-inflammatory effects as well as being an oxygen radical scavenger. In an attempt to elucidate if N-acetylcysteine is capable of preventing the changes caused by secretory otitis media and ventilation tubes we administered different doses of the substance locally to the middle ear of an animal model. The results showed that N-acetylcysteine reduced the extent of the inflammation in the middle-ear mucosa and prevented the long-term fibrotic changes associated with secretory otitis media.
炎症过程和高氧状态。已知这两种情况都会导致黏膜发生变化，尤其是纤维化。已证实N-乙酰半胱氨酸具有抗炎作用，同时还是一种氧自由基清除剂。为了阐明N-乙酰半胱氨酸是否能够预防分泌性中耳炎和通气管引起的变化，我们在动物模型的中耳局部给予了不同剂量的该物质。结果表明，N-乙酰半胱氨酸减轻了中耳黏膜的炎症程度，并预防了与分泌性中耳炎相关的长期纤维化变化。
