Centonze V, Massaro C, Polito B M, Cassiano M A, Di Bari M, Russo P, Cirillo L, Albano O
Istituto di Clinica Medica I, Università degli Studi di Bari.
Clin Ter. 1992 Jan;140(1):11-5.
Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine. Treatment was well tolerated in that the minor side effects reported by a few of the patients never required withdrawal of the drug. Treatment proved useful, as shown by a variety of mental tests, in 69.5% of cases. In 20% conditions remained unchanged and in 9.5% further deterioration was observed. The authors conclude that nimodipine may be considered a useful therapeutic resource for phenomena of brain aging.
40名年龄在65至80岁之间、有轻度至中度脑老化迹象的患者，每天服用90毫克尼莫地平，治疗6个月。治疗耐受性良好，少数患者报告的轻微副作用从未导致停药。各种心理测试表明，69.5%的病例治疗有效。20%的患者病情保持不变，9.5%的患者病情进一步恶化。作者得出结论，尼莫地平可被视为治疗脑老化现象的一种有用的治疗手段。
