复制因子在错配修复中许可核酸外切酶I。

Replication factors license exonuclease I in mismatch repair.

作者信息

Surtees Jennifer A, Alani Eric

机构信息

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.

出版信息

Mol Cell. 2004 Jul 23;15(2):164-6. doi: 10.1016/j.molcel.2004.07.004.

DOI:10.1016/j.molcel.2004.07.004

PMID:15260965

Abstract

A key question in the eukaryotic mismatch repair field is how strand excision is coordinated with mismatch recognition. In a recent issue of Molecular Cell, Dzantiev et al. present evidence that the replication factors PCNA and RFC modulate the directionality of EXOI-mediated excision.

摘要

真核生物错配修复领域的一个关键问题是，链切除如何与错配识别相协调。在最近一期的《分子细胞》杂志上，赞季耶夫等人提供了证据，证明复制因子增殖细胞核抗原（PCNA）和复制因子C（RFC）可调节EXOI介导的切除的方向性。