Insall Robert H, Machesky Laura M
School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
Cell. 2004 Jul 23;118(2):140-1. doi: 10.1016/j.cell.2004.07.005.
Cdc42 is a key regulator of cell polarity and actin dynamics. One of its effectors, WASP, initiates the assembly of new actin filaments. In this issue of Cell, show that a previously unknown regulator named Toca-1 is required for Cdc42 to activate WASP. This discovery changes our picture of how small GTPases and multiple other signals converge to stimulate actin polymerization and cell motility.
Cdc42是细胞极性和肌动蛋白动力学的关键调节因子。其效应器之一WASP可启动新肌动蛋白丝的组装。在本期《细胞》杂志中，研究表明，Cdc42激活WASP需要一种名为Toca-1的此前未知的调节因子。这一发现改变了我们对于小GTP酶和多种其他信号如何汇聚以刺激肌动蛋白聚合和细胞运动的认识。
