眼睛颜色：通向色素沉着基因和祖先血统的窗口。

Eye colour: portals into pigmentation genes and ancestry.

作者信息

Sturm Richard A, Frudakis Tony N

机构信息

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

出版信息

Trends Genet. 2004 Aug;20(8):327-32. doi: 10.1016/j.tig.2004.06.010.

DOI:10.1016/j.tig.2004.06.010

PMID:15262401

Abstract

Several recent papers have tried to address the genetic determination of eye colour via microsatellite linkage, testing of pigmentation candidate gene polymorphisms and the genome wide analysis of SNP markers that are informative for ancestry. These studies show that the OCA2 gene on chromosome 15 is the major determinant of brown and/or blue eye colour but also indicate that other loci will be involved in the broad range of hues seen in this trait in Europeans.

摘要

最近有几篇论文试图通过微卫星连锁、色素沉着候选基因多态性测试以及对有助于确定祖先的单核苷酸多态性（SNP）标记进行全基因组分析来探讨眼睛颜色的遗传决定因素。这些研究表明，15号染色体上的OCA2基因是棕色和/或蓝色眼睛颜色的主要决定因素，但也表明其他基因座会参与欧洲人这一性状中所见的广泛色调变化。