抗体类别转换：将S区可及性与转录解偶联

Antibody class switching: uncoupling S region accessibility from transcription.

作者信息

Kaminski Denise A, Stavnezer Janet

机构信息

Department of Molecular Genetics and Microbiology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

出版信息

Trends Genet. 2004 Aug;20(8):337-40. doi: 10.1016/j.tig.2004.06.008.

DOI:10.1016/j.tig.2004.06.008

PMID:15262403

Abstract

Immunogloblin class switch recombination (CSR) is a regulated process that changes antibody effector functions. Recently, Nambu et al. showed that histone acetylation is induced at switch (S) regions undergoing CSR; however, histone acetylation without accompanying S region transcription is insufficient to attract activation-induced cytidine deaminase (AID), which is required for CSR. They also show that AID can associate with RNA polymerase II. These results support the model that germline transcripts are required to form single-stranded DNA, the AID substrate and further suggest that AID is recruited to S regions by the transcriptional machinery.

摘要

免疫球蛋白类别转换重组（CSR）是一个改变抗体效应功能的调控过程。最近，ambu等人表明，在经历CSR的转换（S）区域会诱导组蛋白乙酰化；然而，没有伴随S区域转录的组蛋白乙酰化不足以吸引CSR所需的激活诱导胞苷脱氨酶（AID）。他们还表明，AID可以与RNA聚合酶II结合。这些结果支持了这样一个模型，即种系转录本是形成单链DNA（AID的底物）所必需的，并且进一步表明AID是由转录机制招募到S区域的。