年龄对人类 B 细胞和体液免疫的影响。
Age effects on B cells and humoral immunity in humans.
机构信息
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA.
出版信息
Ageing Res Rev. 2011 Jul;10(3):330-5. doi: 10.1016/j.arr.2010.08.004. Epub 2010 Aug 20.
Abstract
Both humoral and cellular immune responses are impaired in aged individuals, leading to decreased vaccine responses. Although T cell defects occur, defects in B cells play a significant role in age-related humoral immune changes. The ability to undergo class switch recombination (CSR), the enzyme for CSR, AID (activation-induced cytidine deaminase) and the transcription factor E47 are all decreased in aged stimulated B cells. We here present an overview of age-related changes in human B cell markers and functions, and also discuss some controversies in the field of B cell aging.
摘要
体液免疫和细胞免疫应答在老年人中均受损，导致疫苗应答降低。尽管 T 细胞缺陷发生，但 B 细胞缺陷在与年龄相关的体液免疫变化中起着重要作用。在老年受刺激的 B 细胞中，同种型转换重组（CSR）的能力、CSR 的酶、AID（激活诱导的胞嘧啶脱氨酶）和转录因子 E47 均降低。我们在此概述了人类 B 细胞标志物和功能随年龄增长的变化，并讨论了 B 细胞衰老领域的一些争议。
相似文献
1
Age effects on B cells and humoral immunity in humans.年龄对人类 B 细胞和体液免疫的影响。
Ageing Res Rev. 2011 Jul;10(3):330-5. doi: 10.1016/j.arr.2010.08.004. Epub 2010 Aug 20.
2
Age effects on mouse and human B cells.年龄对小鼠和人类 B 细胞的影响。
Immunol Res. 2013 Dec;57(1-3):354-60. doi: 10.1007/s12026-013-8440-9.
3
Effect of age on the immunoglobulin class switch.年龄对免疫球蛋白类别转换的影响。
Crit Rev Immunol. 2004;24(5):297-320. doi: 10.1615/critrevimmunol.v24.i5.10.
4
Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells.衰老会下调人类B细胞中的转录因子E2A、激活诱导的胞苷脱氨酶以及免疫球蛋白类别转换。
J Immunol. 2008 Apr 15;180(8):5283-90. doi: 10.4049/jimmunol.180.8.5283.
5
Aging affects human B cell responses.衰老是会影响人类 B 细胞反应的。
J Clin Immunol. 2011 Jun;31(3):430-5. doi: 10.1007/s10875-010-9501-7. Epub 2011 Feb 12.
6
Effects of aging on B cell function.衰老对B细胞功能的影响。
Curr Opin Immunol. 2009 Aug;21(4):425-30. doi: 10.1016/j.coi.2009.06.001. Epub 2009 Jul 14.
7
E47 retroviral rescue of intrinsic B-cell defects in senescent mice.E47 逆转录病毒拯救衰老小鼠内在 B 细胞缺陷。
Aging Cell. 2011 Apr;10(2):327-37. doi: 10.1111/j.1474-9726.2011.00673.x. Epub 2011 Feb 25.
8
Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF.衰老的小鼠B细胞经抗CD40或BAFF诱导后，类别转换能力下降。
Exp Gerontol. 2007 Mar;42(3):192-203. doi: 10.1016/j.exger.2006.09.003. Epub 2006 Oct 25.
9
The generation of memory B cells is maintained, but the antibody response is not, in the elderly after repeated influenza immunizations.在反复进行流感疫苗接种后，老年人体内记忆B细胞的生成得以维持，但抗体反应却并非如此。
Vaccine. 2016 May 27;34(25):2834-40. doi: 10.1016/j.vaccine.2016.04.023. Epub 2016 Apr 20.
10
A molecular mechanism for TNF-α-mediated downregulation of B cell responses.TNF-α 介导体液免疫反应下调的分子机制。
J Immunol. 2012 Jan 1;188(1):279-86. doi: 10.4049/jimmunol.1003964. Epub 2011 Nov 23.
引用本文的文献
1
Stromal senescence contributes to age-related increases in cancer.基质衰老导致癌症随年龄增长而增加。
Nat Rev Cancer. 2025 Aug 4. doi: 10.1038/s41568-025-00840-9.
2
A 22 month prospective assessment of neutralizing and IgG antibody levels against SARS-CoV-2 variants following homologous and heterologous BNT162b2 boosting.同源和异源BNT162b2加强免疫后针对SARS-CoV-2变异株的中和抗体和IgG抗体水平的22个月前瞻性评估。
Sci Rep. 2025 Jul 1;15(1):21175. doi: 10.1038/s41598-025-05377-3.
3
Broadly Neutralizing Antibody Characteristics in Hepatitis C Virus Infection and Implications for Vaccine Design.丙型肝炎病毒感染中的广泛中和抗体特征及其对疫苗设计的意义。
Vaccines (Basel). 2025 Jun 6;13(6):612. doi: 10.3390/vaccines13060612.
4
Immunosenescence and Inflammaging in Dogs and Cats: A Narrative Review.犬猫的免疫衰老与炎症衰老：一篇综述
J Vet Intern Med. 2025 Jul-Aug;39(4):e70159. doi: 10.1111/jvim.70159.
5
Aging-associated changes in immunological parameters: Implications for COVID-19 immune response in the elderly.免疫参数的衰老相关变化：对老年人COVID-19免疫反应的影响。
Physiol Rep. 2025 May;13(10):e70364. doi: 10.14814/phy2.70364.
6
Zinc deficiency as possible link between immunosenescence and age-related diseases.锌缺乏可能是免疫衰老与年龄相关疾病之间的联系。
Immun Ageing. 2025 May 19;22(1):19. doi: 10.1186/s12979-025-00511-1.
7
The Dynamics of Antibody Titres Against SARS-CoV-2 in Vaccinated Healthcare Workers: A Systemic Literature Review.接种疫苗的医护人员体内抗SARS-CoV-2抗体滴度的动态变化：一项系统文献综述
Vaccines (Basel). 2024 Dec 16;12(12):1419. doi: 10.3390/vaccines12121419.
8
SARS-CoV-2 Immunization Index in the Academic Community: A Retrospective Post-Vaccination Study.学术界的SARS-CoV-2免疫指数：一项疫苗接种后的回顾性研究。
Infect Dis Rep. 2024 Nov 25;16(6):1084-1097. doi: 10.3390/idr16060088.
9
Effects of Supranutritional Selenium Supplementation During Different Trimesters of Pregnancy on Humoral Immunity in Beef Cattle at Parturition.孕期不同阶段超营养水平补充硒对肉牛分娩时体液免疫的影响。
Biol Trace Elem Res. 2024 Dec 20. doi: 10.1007/s12011-024-04457-1.
10
Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma.B细胞衰老相关基因作为前列腺腺癌风险标志物的预后意义
Transl Cancer Res. 2024 Nov 30;13(11):5771-5783. doi: 10.21037/tcr-24-724. Epub 2024 Nov 27.
本文引用的文献
1
Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans.老年人对季节性流感疫苗接种的 B 细胞反应存在固有缺陷。
Vaccine. 2010 Nov 29;28(51):8077-84. doi: 10.1016/j.vaccine.2010.10.023. Epub 2010 Oct 23.
2
Influenza vaccination in the elderly: seeking new correlates of protection and improved vaccines.老年人的流感疫苗接种：寻找新的保护相关因素及改进疫苗
Aging health. 2008 Dec 1;4(6):603-613. doi: 10.2217/1745509X.4.6.603.
3
Immunosenescence and influenza vaccine efficacy.免疫衰老与流感疫苗效力
Curr Top Microbiol Immunol. 2009;333:413-29. doi: 10.1007/978-3-540-92165-3_20.
4
A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people.双阴性（IgD-CD27-）B细胞群体在老年人外周血中增多。
Mech Ageing Dev. 2009 Oct;130(10):681-90. doi: 10.1016/j.mad.2009.08.003. Epub 2009 Aug 19.
5
Generating memory with vaccination.通过接种疫苗产生记忆。
Eur J Immunol. 2009 Aug;39(8):2100-5. doi: 10.1002/eji.200939550.
6
Effects of aging on B cell function.衰老对B细胞功能的影响。
Curr Opin Immunol. 2009 Aug;21(4):425-30. doi: 10.1016/j.coi.2009.06.001. Epub 2009 Jul 14.
7
Immunosenescence and vaccine failure in the elderly.老年人的免疫衰老与疫苗失效
Aging Clin Exp Res. 2009 Jun;21(3):201-9. doi: 10.1007/BF03324904.
8
Immunosenescence: what does it mean to health outcomes in older adults?免疫衰老：对老年人的健康结果意味着什么？
Curr Opin Immunol. 2009 Aug;21(4):418-24. doi: 10.1016/j.coi.2009.05.023. Epub 2009 Jun 29.
9
B-cell responses to vaccination at the extremes of age.不同年龄段接种疫苗后的B细胞反应。
Nat Rev Immunol. 2009 Mar;9(3):185-94. doi: 10.1038/nri2508.
10
Cytomegalovirus and human immunosenescence.巨细胞病毒与人类免疫衰老
Rev Med Virol. 2009 Jan;19(1):47-56. doi: 10.1002/rmv.598.
Zotero 插件