双着丝粒（19；21）（p13；p13），一种出现在费城染色体阳性急性淋巴细胞白血病病例中的新型染色体异常。
Dicentric (19;21)(p13;p13), a novel chromosomal abnormality occurring in a case of Philadelphia chromosome-positive acute lymphoblastic leukemia.
作者信息
Schilling Georgia, Dierlamm Judith, Murga Penas Eva Maria, Hinz Kristina, Seeger Doris, Hossfeld Dieter Kurt
机构信息
Medizinische Klinik II, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
出版信息
Cancer Genet Cytogenet. 2004 Jul 15;152(2):129-31. doi: 10.1016/j.cancergencyto.2003.10.018.
We report on a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia, who acquired a novel chromosomal abnormality, a dic(19;21)(p13;p13), during relapse of the disease. The cytogenetic result was confirmed by fluorescence in situ hybridization using alpha-satellite and library probes specific for chromosomes 19 and 21, respectively, as well as a chromosome 19q13.1-specific DNA probe. In our case, the dic(19;21) represents a secondary genetic change and was associated with disease progression and poor prognosis.
我们报告了一名费城染色体阳性急性淋巴细胞白血病患者，该患者在疾病复发期间获得了一种新的染色体异常，即双着丝粒染色体dic(19;21)(p13;p13)。通过分别使用针对19号和21号染色体的α卫星和文库探针以及19号染色体q13.1特异性DNA探针进行荧光原位杂交，证实了细胞遗传学结果。在我们的病例中，dic(19;21)代表一种继发性基因改变，与疾病进展和不良预后相关。
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