一名急性淋巴细胞白血病患者的继发性费城染色体。

Secondary Philadelphia chromosome in a patient with acute lymphoblastic leukemia.

作者信息

Chen Lin, Stamatoullas Aspasia, Bastard Christian, Tilly Hervé

机构信息

Department of Hematology, Cytogenetic Department, Centre Henri Becquerel, 1 Rue D'amiens, Rouen, France.

出版信息

Cancer Genet Cytogenet. 2004 Jul 15;152(2):132-5. doi: 10.1016/j.cancergencyto.2003.11.006.

DOI:10.1016/j.cancergencyto.2003.11.006

PMID:15262432

Abstract

We report the case of a patient with acute lymphoblastic leukemia who developed a secondary Philadelphia chromosome-positive clone (Ph(+)). Although the Ph was not detected at diagnosis with conventional cytogenetic analysis and with molecular methods (reverse transcriptase polymerase chain reaction), the Ph was detected with the same techniques at relapse. This anomaly is usually related to the initiation of the disease, but can be a late event related to progression. We discuss these hypotheses and review the literature.

摘要

我们报告了一例急性淋巴细胞白血病患者，该患者出现了继发性费城染色体阳性克隆（Ph(+)）。尽管在诊断时采用传统细胞遗传学分析和分子方法（逆转录聚合酶链反应）未检测到费城染色体，但在复发时采用相同技术检测到了该染色体。这种异常通常与疾病的起始有关，但也可能是与疾病进展相关的晚期事件。我们讨论了这些假说并回顾了相关文献。