Bhattacharyya D, Pandit S, Mukherjee R, Das N, Sur T K
Department of Pharmacology, Dr. B. C. Roy Post Graduate Institute of Basic Medical Sciences, 244B, Acharya J. C. Bose Road, Kolkata 700 020.
Indian J Physiol Pharmacol. 2003 Oct;47(4):435-40.
The effect of Himoliv (HV) was evaluated in carbon tetrachloride or paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of either carbon tetrachloride (CCl4, 1 ml/kg, 50% v/v with olive oil, s.c.) or paracetamol (PC, 1 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and serum alkaline phosphatase (ALP) and hepatic thiobarbituric acid reacting substances (TBARS) and superoxide dismutase (SOD). HV pretreatment (0.5 and 1.0 ml/kg, p.o.) significantly (P < 0.001) reduced CCl4 or PC-induced elevations of the levels of SGOT, SGPT, ALP and TBARS, while the reduced concentration of SOD due to CCl4 or PC was reversed. Silymarin (25 mg/ kg, p.o.), a known hepatoprotective drug showed similar results.
在四氯化碳或对乙酰氨基酚诱导的大鼠肝毒性实验中评估了希莫利夫（HV）的效果。通过单次给予四氯化碳（CCl4，1 ml/kg，50% v/v溶于橄榄油，皮下注射）或对乙酰氨基酚（PC，1 g/kg，口服）来诱导肝坏死。血清谷氨酸草酰乙酸转氨酶（SGOT）、血清谷氨酸丙酮酸转氨酶（SGPT）、血清碱性磷酸酶（ALP）以及肝组织硫代巴比妥酸反应物质（TBARS）和超氧化物歧化酶（SOD）水平升高证明了肝损伤。HV预处理（0.5和1.0 ml/kg，口服）显著（P < 0.001）降低了CCl4或PC诱导的SGOT、SGPT、ALP和TBARS水平的升高，同时逆转了因CCl4或PC导致的SOD浓度降低。水飞蓟宾（25 mg/kg，口服），一种已知的肝保护药物，显示出类似的结果。
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