• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多草药配方对大鼠多种肝毒性剂的肝保护作用。

Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.

作者信息

Tatiya Anil U, Surana Sanjay J, Sutar Manisha P, Gamit Nehal H

机构信息

Department of Pharmacognosy, Medicinal Plant Research Laboratory, R.C. Patel institute of Pharmaceutical Education and Research, Shirpur - 425 405, Maharashtra, India.

出版信息

Pharmacognosy Res. 2012 Jan;4(1):50-6. doi: 10.4103/0974-8490.91040.

DOI:10.4103/0974-8490.91040
PMID:22224062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3250040/
Abstract

BACKGROUND

Individually Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn.(Euphorbiaceae) and Phyllanthus emblica Linn. single plant extracts have been reported to have hepatoprotective activity. However, literature survey shows that no sufficient scientific data has been publish on pharmacological evaluation of these plants in combined form.

METHOD

Hepatoprotective activity of the polyherbal hepatoprotaective formulation (PHF)-containing spray-dried aqueous extracts of Andrographis paniculata Nees. (Acanthaceae), Phyllanthus niruri Linn. (Euphorbiaceae) and Phyllanthus emblica Linn. (Euphorbiaceae), was screened against paracetamol, carbon tetrachloride (CCl(4)), and ethanol-induced hepatic damage in rats. PHF was evaluated by measuring levels of serum marker enzymes like SGOT, SGPT, ALP, direct bilirubin (DB), and lactate dehydrogenase (LDH). The histological studies were also studied support the biochemical parameters. Silymarin was used as standard drug.

RESULTS

Administration of PHF (100 and 200 mg/kg p.o.) significantly inhibited paracetamol, CCl(4) and ethanol-induced elevation levels of SGPT, SGOT, ALP, DB and LDH. A comparative histopathological study of liver exhibited almost normal architecture as compared to toxicant group.

CONCLUSION

Results suggests that the hepatoprotective effects of PHF might be useful for liver protection due to combined action of all plant extracts along with their phytoconstituents.

摘要

背景

据报道，穿心莲（爵床科）、叶下珠（大戟科）和余甘子单株植物提取物具有肝脏保护活性。然而，文献调查表明，尚未有足够的科学数据公布这些植物联合使用的药理学评价。

方法

对含有穿心莲（爵床科）、叶下珠（大戟科）和余甘子（大戟科）喷雾干燥水提取物的多草药肝脏保护制剂（PHF）进行肝脏保护活性筛选，以对乙酰氨基酚、四氯化碳（CCl₄）和乙醇诱导的大鼠肝损伤为模型。通过测量血清标志物酶如谷草转氨酶（SGOT）、谷丙转氨酶（SGPT）、碱性磷酸酶（ALP）、直接胆红素（DB）和乳酸脱氢酶（LDH）的水平来评估PHF。组织学研究也用于支持生化参数。水飞蓟宾用作标准药物。

结果

给予PHF（100和200mg/kg口服）可显著抑制对乙酰氨基酚、CCl₄和乙醇诱导的SGPT、SGOT、ALP、DB和LDH水平升高。与中毒组相比，肝脏的比较组织病理学研究显示几乎正常的结构。

结论

结果表明，由于所有植物提取物及其植物成分的联合作用，PHF的肝脏保护作用可能对肝脏保护有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/b094f7e85f5f/PR-4-50-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/260cf0f48bff/PR-4-50-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/ee99bc524741/PR-4-50-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/cff4d02738c0/PR-4-50-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/b094f7e85f5f/PR-4-50-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/260cf0f48bff/PR-4-50-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/ee99bc524741/PR-4-50-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/cff4d02738c0/PR-4-50-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f31/3250040/b094f7e85f5f/PR-4-50-g006.jpg

相似文献

1
Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.多草药配方对大鼠多种肝毒性剂的肝保护作用。
Pharmacognosy Res. 2012 Jan;4(1):50-6. doi: 10.4103/0974-8490.91040.
2
Pharmacological Evaluation of Hepatoprotective Activity of AHPL/AYTAB/0613 Tablet in Carbon Tetrachloride-, Ethanol-, and Paracetamol-Induced Hepatotoxicity Models in Wistar Albino Rats.AHPL/AYTAB/0613片对Wistar白化大鼠四氯化碳、乙醇和对乙酰氨基酚诱导的肝毒性模型的肝保护活性的药理学评价。
Pharmacognosy Res. 2017 Dec;9(Suppl 1):S41-S47. doi: 10.4103/pr.pr_44_17.
3
Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats.评价阿玛尔卡迪酥油对四氯化碳诱导的大鼠肝损伤的保肝作用。
J Ethnopharmacol. 2004 Feb;90(2-3):229-32. doi: 10.1016/j.jep.2003.09.037.
4
Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties.从大戟科叶下珠属植物叶下珠中分离得到的蛋白质，通过其抗氧化特性，对四氯化碳诱导的肝损伤发挥肝脏保护作用。
Food Chem Toxicol. 2007 May;45(5):817-26. doi: 10.1016/j.fct.2006.10.029. Epub 2006 Nov 11.
5
Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity.针对对乙酰氨基酚诱导的肝毒性的草药肝保护制剂的设计与评估
J Young Pharm. 2013 Dec;5(4):180-7. doi: 10.1016/j.jyp.2013.12.003. Epub 2014 Jan 7.
6
Hepatoprotective effect of Anacyclus pyrethrum Linn. against antitubercular drug-induced hepatotoxicity in SD rats.刺苞术对SD大鼠抗结核药物诱导的肝毒性的保肝作用。
J Complement Integr Med. 2016 Sep 1;13(3):295-300. doi: 10.1515/jcim-2016-0001.
7
Protective effect of Tritone (Livosone) on oxidative DNA damage and its hepatoprotective potential against various hepatotoxic agent in wistar rats.曲通（利沃松）对Wistar大鼠氧化DNA损伤的保护作用及其对各种肝毒性剂的肝保护潜力。
Exp Toxicol Pathol. 2017 Mar 2;69(3):153-161. doi: 10.1016/j.etp.2016.12.005. Epub 2017 Jan 4.
8
In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization.深入研究印度叶下珠的保肝作用机制：体外和体内研究及其化学成分表征。
PLoS One. 2020 Jan 15;15(1):e0226185. doi: 10.1371/journal.pone.0226185. eCollection 2020.
9
Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats.线纹耳草叶提取物对四氯化碳所致大鼠肝损伤的保肝作用
Phytother Res. 2008 Jan;22(1):124-6. doi: 10.1002/ptr.2250.
10
Hepatoprotective Effect of A Polyherbal Extract Containing Andrographis Paniculata, Tinospora Cordifolia and Solanum Nigrum Against Paracetamol Induced Hepatotoxicity.一种含有穿心莲、心叶青牛胆和龙葵的多草药提取物对扑热息痛诱导的肝毒性的肝保护作用。
Pharmacogn Mag. 2015 Oct;11(Suppl 3):S375-9. doi: 10.4103/0973-1296.168945.

引用本文的文献

1
Biosynthesis and assessment of antibacterial and antioxidant activities of silver nanoparticles utilizing Cassia occidentalis L. seed.利用番泻叶种子合成并评价银纳米粒子的抗菌和抗氧化活性。
Sci Rep. 2024 Mar 27;14(1):7243. doi: 10.1038/s41598-024-57823-3.
2
mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis.蘑菇为糖尿病、高脂血症和肝变性的管理提供了新见解：一项综合分析。
Food Sci Nutr. 2021 Jun 24;9(8):4364-4374. doi: 10.1002/fsn3.2407. eCollection 2021 Aug.
3
Hepatoprotective Effects of Different Extracts From Against CCl-Induced Acute Liver Injury in Mice.

本文引用的文献

1
Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity.余甘子50%水醇果提取物对抗结核药物所致肝毒性的保护作用。
Phytother Res. 2005 Mar;19(3):193-7. doi: 10.1002/ptr.1631.
2
Hepatoprotective effect of Himoliv, a polyherbal formulation in rats.复方草药制剂希莫利夫对大鼠的肝脏保护作用。
Indian J Physiol Pharmacol. 2003 Oct;47(4):435-40.
3
Preliminary evaluation of the antihepatotoxic activity of Kamilari, a polyherbal formulation.复方草药制剂卡米拉里抗肝毒性活性的初步评估
[植物名称]不同提取物对四氯化碳诱导的小鼠急性肝损伤的保肝作用 。（原文中“From”后面缺少具体植物名称）
Front Pharmacol. 2021 Jul 5;12:664607. doi: 10.3389/fphar.2021.664607. eCollection 2021.
4
Protective role of apple cider vinegar (APCV) in CCl-induced renal damage in wistar rats.苹果醋（APCV）对四氯化碳诱导的Wistar大鼠肾损伤的保护作用。
Metabol Open. 2020 Sep 30;8:100063. doi: 10.1016/j.metop.2020.100063. eCollection 2020 Dec.
5
In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitro and in vivo studies and its chemical characterization.深入研究印度叶下珠的保肝作用机制：体外和体内研究及其化学成分表征。
PLoS One. 2020 Jan 15;15(1):e0226185. doi: 10.1371/journal.pone.0226185. eCollection 2020.
6
Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats.不同干预方式下骨髓间充质干细胞移植对肝硬化大鼠影响的观察
Braz J Med Biol Res. 2019 Feb 25;52(3):e7879. doi: 10.1590/1414-431X20187879.
7
Exploratory Studies of (-)-Epicatechin, a Bioactive Compound of , on the Antioxidant Enzymes and Oxidative Stress Markers in D-galactosamine-induced Hepatitis in Rats: A Study with Reference to Clinical Prospective.（-）-表儿茶素（一种生物活性化合物）对D-半乳糖胺诱导的大鼠肝炎中抗氧化酶和氧化应激标志物的探索性研究：一项参考临床前景的研究
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S56-S62. doi: 10.4103/0973-1296.203973. Epub 2017 Apr 7.
8
Maltol, a food flavoring agent, attenuates acute alcohol-induced oxidative damage in mice.麦芽酚是一种食品调味剂，可减轻小鼠急性酒精诱导的氧化损伤。
Nutrients. 2015 Jan 20;7(1):682-96. doi: 10.3390/nu7010682.
9
The potential protective effect of Physalis peruviana L. against carbon tetrachloride-induced hepatotoxicity in rats is mediated by suppression of oxidative stress and downregulation of MMP-9 expression.灯笼果对四氯化碳诱导的大鼠肝毒性的潜在保护作用是通过抑制氧化应激和下调MMP-9表达来介导的。
Oxid Med Cell Longev. 2014;2014:381413. doi: 10.1155/2014/381413. Epub 2014 Apr 27.
10
Design and evaluation of herbal hepatoprotective formulation against paracetamol induced liver toxicity.针对对乙酰氨基酚诱导的肝毒性的草药肝保护制剂的设计与评估
J Young Pharm. 2013 Dec;5(4):180-7. doi: 10.1016/j.jyp.2013.12.003. Epub 2014 Jan 7.
J Ethnopharmacol. 2004 Mar;91(1):99-104. doi: 10.1016/j.jep.2003.12.011.
4
Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats.评价阿玛尔卡迪酥油对四氯化碳诱导的大鼠肝损伤的保肝作用。
J Ethnopharmacol. 2004 Feb;90(2-3):229-32. doi: 10.1016/j.jep.2003.09.037.
5
A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.一种测定血清谷草转氨酶和谷丙转氨酶的比色法。
Am J Clin Pathol. 1957 Jul;28(1):56-63. doi: 10.1093/ajcp/28.1.56.
6
Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury.决明叶提取物对酒精性肝损伤大鼠的作用
J Nutr Biochem. 2003 Aug;14(8):452-8. doi: 10.1016/s0955-2863(03)00053-6.
7
Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in the alleviation of carbon tetrachloride-induced acute hepatotoxicity in the rat.迷迭香（唇形科）对减轻四氯化碳诱导的大鼠急性肝毒性的有效性评估。
J Ethnopharmacol. 2002 Jul;81(2):145-54. doi: 10.1016/s0378-8741(02)00090-9.
8
Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents.小檗碱对啮齿动物化学诱导肝毒性的预防和治疗作用研究。
Fitoterapia. 2000 Feb;71(1):25-33. doi: 10.1016/s0367-326x(99)00098-2.
9
Hepatoprotective and antioxidant property of Andrographis paniculata (Nees) in BHC induced liver damage in mice.穿心莲对苯并六氯诱导的小鼠肝损伤的保肝及抗氧化特性。
Indian J Exp Biol. 2001 Jan;39(1):41-6.
10
Hepatoprotective activity of Emblica officinalis and Chyavanaprash.余甘子和Chyavanaprash的保肝活性。
J Ethnopharmacol. 2000 Sep;72(1-2):135-40. doi: 10.1016/s0378-8741(00)00219-1.