衰老过程中的固有免疫：对巨噬细胞功能的影响。

Innate immunity in aging: impact on macrophage function.

作者信息

Plowden Julie, Renshaw-Hoelscher Mary, Engleman Carrie, Katz Jacqueline, Sambhara Suryaprakash

机构信息

Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

出版信息

Aging Cell. 2004 Aug;3(4):161-7. doi: 10.1111/j.1474-9728.2004.00102.x.

DOI:10.1111/j.1474-9728.2004.00102.x

PMID:15268749

Abstract

Innate and adaptive immune functions decline with age, leading to increased susceptibility to infectious diseases and cancer, and reduced responses to preventive vaccination in the elderly population. Macrophages function as 'pathogen sensors' and play an important role in the initiation of inflammatory responses, elimination of pathogens, manipulation of the adaptive immune response and reparation of damaged tissue. In this paper, we review the literature addressing the impact of aging on the macrophage population.

摘要

先天性和适应性免疫功能会随着年龄增长而衰退，导致老年人群对传染病和癌症的易感性增加，以及对预防性疫苗接种的反应减弱。巨噬细胞作为“病原体传感器”，在炎症反应的启动、病原体的清除、适应性免疫反应的调控以及受损组织的修复中发挥着重要作用。在本文中，我们综述了关于衰老对巨噬细胞群体影响的文献。