8号染色体短臂的等位基因失衡表明胃癌患者生存率较低。
Allelic imbalance of 8p indicates poor survival in gastric cancer.
作者信息
French Amy J, Petroni Gina, Thibideau Stephen N, Smolkin Mark, Bissonette Eric, Roviello Franco, Harper Jeffrey C, Koch Benjamin R, Anderson Sarah A, Hebbring Scott J, Powell Steven M
机构信息
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
出版信息
J Mol Diagn. 2004 Aug;6(3):243-52. doi: 10.1016/S1525-1578(10)60517-X.
Gastric cancer is a common tumor worldwide and a tremendous health burden. However, the underlying mechanisms of tumorigenesis in this cancer's development are primarily undefined. Allelic imbalance (AI) of 8p has been reported in many cancers, yet, the target(s) of alteration and the importance of allelic imbalance on this chromosomal arm in gastric carcinoma development remained to be characterized. Our findings confirmed a high rate of AI on 8p in gastric cancers. Moreover, we demonstrated that AI on 8p, either overall or at marker D8S560, was associated with poorer survival in patients with gastric cancer. Finally, gastric cancers with a high rate of microsatellite instability were significantly associated with noncardia tumors and with female gender.
胃癌是全球常见的肿瘤，也是巨大的健康负担。然而，这种癌症发生发展过程中肿瘤发生的潜在机制主要尚不清楚。8号染色体短臂（8p）的等位基因不平衡（AI）在许多癌症中都有报道，但是，该染色体臂上改变的靶点以及等位基因不平衡在胃癌发生发展中的重要性仍有待明确。我们的研究结果证实胃癌中8p的AI发生率很高。此外，我们还证明，8p的AI，无论是总体上还是在标记物D8S560处，都与胃癌患者较差的生存率相关。最后，微卫星不稳定性发生率高的胃癌与非贲门部肿瘤以及女性显著相关。
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