手性环糊精诱导的分散水相反应体系中不溶性（R,S）-酮洛芬乙酯的对映选择性水解

Enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester in dispersed aqueous reaction system induced by chiral cyclodextrin.

作者信息

Kim Sun-Hwa, Kim Tae-Kwon, Shin Gab-Sang, Lee Kwang-Woo, Shin Hyun-Dong, Lee Yong-Hyun

机构信息

Department of Genetic Engineering, College of Natural Sciences, Kyungpook National University, Daegu 702-701, South Korea.

出版信息

Biotechnol Lett. 2004 Jun;26(12):965-9. doi: 10.1023/b:bile.0000030040.13828.d7.

DOI:10.1023/b:bile.0000030040.13828.d7

PMID:15269520

Abstract

The enantioselective hydrolysis of insoluble (R,S)-ketoprofen ethyl ester to the optically active (S)-ketoprofen was carried out in a dispersed aqueous lipase reaction system induced by the inclusion of chiral cyclodextrins for complexation of the substrate. Hydroxypropyl-beta-cyclodextrin was the most effective chiral selector and disperser giving an enantiomeric excess and conversion yield of 0.99 and 0.49, respectively.

摘要

在由手性环糊精诱导形成的分散水相脂肪酶反应体系中，通过包合底物进行不溶性（R,S）-酮洛芬乙酯的对映选择性水解，生成光学活性的（S）-酮洛芬。羟丙基-β-环糊精是最有效的手性选择剂和分散剂，对映体过量值和转化率分别为0.99和0.49。