Krishnaiah P, Reddy V L N, Venkataramana G, Ravinder K, Srinivasulu M, Raju T V, Ravikumar K, Chandrasekar D, Ramakrishna S, Venkateswarlu Y
Natural Products Laboratory, Organic Chemistry Division-I, X-ray Crystallographic Division, and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
J Nat Prod. 2004 Jul;67(7):1168-71. doi: 10.1021/np030503t.
Three new lamellarin alkaloids, lamellarins gamma (1), alpha (2), and epsilon (3), along with eight known lamellarin alkaloids, lamellarins M (4), K (5), K-diacetate (6), K-triacetate (7), U (8), I (9), C-diacetate (10), and X-triacetate (11), have been isolated from the Indian ascidian Didemnum obscurum. The structures of 1-11 were established using standard spectroscopic techniques. The structure of lamellarin K-triacetate (7) was further confirmed by X-ray crystallographic analysis. The antioxidant properties of lamellarin gamma, lamellarin gamma-monoacetate, lamellarins K, U, and I, and lamellarin C-diacetate were evaluated.
从印度海鞘阴暗膜海鞘中分离出了三种新的片螺素生物碱，即片螺素γ（1）、α（2）和ε（3），以及八种已知的片螺素生物碱，片螺素M（4）、K（5）、K - 二乙酸酯（6）、K - 三乙酸酯（7）、U（8）、I（9）、C - 二乙酸酯（10）和X - 三乙酸酯（11）。采用标准光谱技术确定了1 - 11的结构。通过X射线晶体学分析进一步证实了片螺素K - 三乙酸酯（7）的结构。评估了片螺素γ、片螺素γ - 单乙酸酯、片螺素K、U、I以及片螺素C - 二乙酸酯的抗氧化性能。
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