从菲律宾海鞘Perophora namei中分离、鉴定一种新型生物碱——海鞘素，并研究其生物活性。
Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei.
作者信息
Verbitski Sheryl M, Mayne Charles L, Davis Rohan A, Concepcion Gisela P, Ireland Chris M
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
J Org Chem. 2002 Oct 4;67(20):7124-6. doi: 10.1021/jo026012f.
PMID:12354007
Abstract
Chemical investigation of the Philippine ascidian Perophora namei has resulted in the isolation of a novel polycyclic alkaloid, perophoramidine (1). The structure of 1 was determined by the interpretation of 1D/2D NMR and MS data. Dehalogenation of perophoramidine (1) by ammonium formate catalyzed transfer hydrogenation confirmed the type and number of halogen atoms present in 1.
摘要
对菲律宾海鞘Perophora namei进行化学研究，从中分离出一种新型多环生物碱——海鞘素（1）。通过对一维/二维核磁共振和质谱数据的解析确定了1的结构。用甲酸铵催化转移氢化法对海鞘素（1）进行脱卤反应，证实了1中存在的卤素原子类型和数量。
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