哺乳动物中胚层和轴形成的多样性。

Diversity of germ layer and axis formation among mammals.

作者信息

Eakin Guy S, Behringer Richard R

机构信息

Program in Developmental Biology, Baylor College of Medicine and Department of Molecular Genetics, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

出版信息

Semin Cell Dev Biol. 2004 Oct;15(5):619-29. doi: 10.1016/j.semcdb.2004.04.008.

DOI:10.1016/j.semcdb.2004.04.008

PMID:15271307

Abstract

The class mammalia is composed of approximately 4800 extant species. This class is divided into three subclasses, the prototheria (monotremes), metatheria (marsupials), and eutheria. Surprisingly, there is relatively little knowledge about germ layer and axis formation in mammalian species. Most knowledge about these embryonic processes has been obtained from one species, the mouse, Mus musculus. Here we discuss major variations in germ layer and axis formation among mammals. We suggest that more studies of embryonic development in diverse mammalian species are required for an understanding of germ layer and axis formation to provide insights into human biology and disease.

摘要

哺乳纲由大约4800个现存物种组成。该纲分为三个亚纲，即原兽亚纲（单孔目动物）、后兽亚纲（有袋类动物）和真兽亚纲。令人惊讶的是，关于哺乳动物物种中胚层和轴形成的知识相对较少。关于这些胚胎过程的大多数知识是从一个物种——小家鼠（Mus musculus）获得的。在这里，我们讨论哺乳动物之间胚层和轴形成的主要差异。我们认为，需要对更多不同的哺乳动物物种的胚胎发育进行研究，以了解胚层和轴的形成，从而为人类生物学和疾病提供见解。