生长分化因子9（GDF9）和骨形态发生蛋白15（BMP15）信号分子的生理学

Physiology of GDF9 and BMP15 signalling molecules.

作者信息

Juengel J L, Bodensteiner K J, Heath D A, Hudson N L, Moeller C L, Smith P, Galloway S M, Davis G H, Sawyer H R, McNatty K P

机构信息

AgResearch, Wallaceville Animal Research Centre, Ward Street, P.O. Box 40063, Upper Hutt, New Zealand.

出版信息

Anim Reprod Sci. 2004 Jul;82-83:447-60. doi: 10.1016/j.anireprosci.2004.04.021.

DOI:10.1016/j.anireprosci.2004.04.021

PMID:15271472

Abstract

Two related oocyte-derived members of the transforming growth factor-beta (TGF-beta) superfamily, namely growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15, also known as GDF9B), have recently been shown to be essential for ovarian follicular growth. In addition, both proteins have been shown to regulate ovulation rate in sheep, and although it is evident that these growth factors interact both with one another and with other intra- and extra-ovarian factors, the precise mechanisms by which they influence follicular growth and ovulation rate have not been thoroughly elucidated.

摘要

转化生长因子-β（TGF-β）超家族中两个与卵母细胞相关的成员，即生长分化因子9（GDF9）和骨形态发生蛋白15（BMP15，也称为GDF9B），最近已被证明对卵巢卵泡生长至关重要。此外，这两种蛋白质都已被证明可调节绵羊的排卵率，尽管很明显这些生长因子彼此之间以及与其他卵巢内和卵巢外因子相互作用，但其影响卵泡生长和排卵率的精确机制尚未完全阐明。